Kick-off at Chartsworth Stadium is at 19:00.
The Brazilians head into this encounter on the back of clinching their fifth consecutive league title – they did with a 0-0 draw at home against Cape Town City.
And that alone means they can put all the energy into this encounter against Royal AM without worrying too much about other things.
It is for that reason, they rested a number of their key players, including Themba Zwane, Neo Maema, Surprise Ralani in the second half of their clash against Cape Town City.
For Royal AM, reaching the semi-finals of the Nedbank Cup is victory on its own as this is their first season in the topflight.
ROYAL AM VS MAMELODI SUNDOWNS: HOW TO WATCH THE NEDBANK CUP MATCH ON TV
The Tshwane giants have confirmed on their social media platforms that the match against Royal AM will be screened LIVE on SuperSport PSL channel 202.
The build for the encounter is scheduled for 18:30, and the draw for the final will be conducted immediately after the encounter at Chartsworth Stadium.
The SABC Sport will also broadcast the match on SABC 1 with a number of their radio stations also broadcasting the match.
Lastly, The South African will run a live blog for this Nedbank Cup semi-final, and a comprehensive match report will follow immediately after the final whistle.